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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

Fig. 2

EZH2 inhibition potentiates the effect of ATRA in 2D. CyQuant proliferation assay of A RD and B RH30 after treatment with ATRA, GSK343 or in combination relative to DMSO control. Caspase signalling intensity of ATRA and GSK343 combination treatment in C RD and D RH30 cells relative to DMSO control. E Western blots of myogenic marker expression for fractionated RD and RH30 respectively treated with ATRA, GSK343, or combination for 6 days. Data shown are mean values from at least 2 independent experiments; bars, SD. One Way ANOVA was used to analyse statistical significance compared to the DMSO control (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001)

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Clinical Epigenetics

ISSN: 1868-7083

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