Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood

Clinical Epigenetics

Table 2 Differentially methylated position (DMP; q value < 0.05) associated with maternal adverse childhood experiences (ACEs)

ACE	CpG	Methyl. OR	q value	Baseline maximum likelihood (95% CI) % methylated ^a	Maximum likelihood (95% CI) % methylation change ^b	Chr	Position (bp) ^c	Gene annotation	Feature category
Emotional abuse	cg05486260	1.44	0.01	71.03 (65.74, 75.80)	6.92 (4.82, 9.00)	8	139,206,451	FAM135B	Body

^aBaseline measures were obtained from fitted models by plugging in mean values for continuous variables or most-frequently observed values for categorical variables. Thus the baseline prediction is for a female child with gestational age of 273.36 days, whose mother had 1.19 previous births with gestational age \(\ge\) 24 weeks, did not smoke during pregnancy, was married at time of birth, had educational attainment at or below 6th grade, was 25.73 years old at time of birth, and whose cord blood cell type composition was 18.94% CD4 + T cells, 9.12% CD8 + T cells, 0.73% natural killer cells, 18.33% B Cells, 10.92% monocytes, 40.63% granulocytes, 1.33% nucleated red blood cells
^bExposed measures were obtained by plugging in the same values used to represent the mean/most frequently observed individual for baseline and setting exposure variables to 1. The Differences between exposed and baseline methylation were Monte Carlo simulated using 3000 draws from a multivariate normal distribution, followed by inverse logit transformation and subtraction
c. hg19 assembly

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