Fig. 2

Associations of module eigengenes (MEs) with the number of maternal adverse childhood experiences (ACEs). MEs were derived from weighted correlation analysis (WGCNA). The total number of ACEs was modeled linearly or as a categorical variable of 0, 1–3, or 4–10. Bivariate associations were evaluated using Pearson correlations. Adjusted associations were evaluated using models including newborn sex, gestational age, and cord blood estimated cell type proportions, and maternal parity, pre-pregnancy BMI, age at delivery, educational attainment, smoking during pregnancy, and marital status. Where applicable, summaries of associated biological pathways derived from enrichment analyses are displayed parenthetically next to module names