Fig. 4

Significantly differentially methylated CpGs in close proximity to CpGs from original classifier define a recomposed classifier within an independent validation cohort. A Box plots for significant differences in methylation levels between responders (blue color) and non-responders (red color) as assessed by non-parametric wilcoxon rank sum tests in the EXP arm. Methylation levels were determined by MassARRAY assay. B Elements of a recomposed classifier based on a penalized likelihood regression model