Fig. 5

QC6352 triggered senescence by potentially repressing SP1-CDK2 signaling. A Triangular heatmap representing the pairwise correlation among KDM4C and the key pro-senescence genes. B-C Expression correlation between KDM4C with ATF6 (B) and SP1 (C). D-E The Cancer Genome Atlas (TCGA) RNA-sequencing results showing the expression levels of ATF6 (D) or SP1 (E) in the indicated type of patients with gastric cancer. F-G The RNA expression of SP1 (F) and ATF6 (G) in a gastric cancer cohort of TCGA. H-I Kaplan–Meier plots analysis of overall survival (OS), first progression (FP), and post-progression survival (PPS) rates in patients with gastric cancer with high or low SP1 mRNA levels (H), or high or low ATF6 mRNA levels (I). J-K Gastric cancer cells were treated with gradient doses of QC6352 (10 nM and 20 nM), followed by immunoblotting analysis. L Tumor samples derived from the indicated groups were lysed, followed by immunoblotting analysis