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Fig. 3 | Clinical Epigenetics

Fig. 3

From: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

Fig. 3

SSK1 efficiently eliminated QC6352-induced senescent cells. A-B Representative images of cell death (A), quantification of cell death by 7-amino-actinomycin D (7AAD) staining (B) in NCI-N87 and HGC27 cells treated with QC6352 for 96 h in the presence or absence of SSK1. C NCI-N87 and HGC27 cells were sequentially treated with QC6352 and SSK1, followed by immunoblotting analysis. D Representative images of senescence-associated β-galactosidase (SA-β-Gal) staining in gastric cancer cells sequentially treated as indicated. Scale bar, 20 μm

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