Table 2 Top ten canonical pathways for Grim-mAA-associated transcript genes

Neuroinflammation signaling pathway

1.59E−07

AKT3, CD40, CREB3L4, CX3CL1, CX3CR1, CXCL10, FOS, GABRB2, GAD1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, IL1B, MR1, MYD88, NFKB1, NOX1, PIK3CG, SLC1A2, SOD2, TGFB1, TLR4, TLR5, TLR7, TYROBP

Estrogen biosynthesis

1.68E−07

AKR1B15, AKR1C1/AKR1C2, AKR1C3, AKR1C4, CYP1B1, CYP2A6 (includes others), CYP4F8, CYP4X1, HSD17B11, HSD17B13

B cell development

2.48E−07

CD40, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, IL7R, PTPRC, RAG2

ICOS-ICOSL signaling in T helper cells

1.02E−06

AKT3, CD4, CD40, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, IL2RG, ITPR1, LCP2, NFKB1, NFKBIA, PIK3CG, PLEKHA2, PTEN, PTPRC, TRGV8

IL-17A signaling in airway cells

2.82E−06

AKT3, CCL20, CXCL1, CXCL3, MAP2K1, MUC5AC, NFKB1, NFKBIA, PIK3CG, PTEN, TRAF3IP2

PD-1, PD-L1 cancer immunotherapy pathway

4.27E−06

AKT3, CDK2, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, IL2RG, LCP2, MR1, PIK3CG, PTEN, TGFB1

Granulocyte adhesion and diapedesis

9.19E−06

CCL20, CCR2, CLDN1, CLDN10, CX3CL1, CXCL1, CXCL10, CXCL16, CXCL2, CXCL3, CXCL9, IL1B, ITGA4, MSN, SDC4, SELP, SELPLG

NRF2-mediated oxidative stress response

9.40E−06

ABCC1, CBR1, CYP2A6 (includes others), DNAJC14, FOS, GCLC, GCLM, GPX2, GSR, GSTA4, JUNB, MAP2K1, MAP2K6, NQO1, PIK3CG, PRDX1, SOD1, SOD2, TXNRD1

PKCθ signaling in T lymphocytes

1.32E−05

CACNA1C, CACNA1D, CACNA2D3, CACNG4, CACNG6, CD4, FOS, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, ITPR1, LCP2, MAP3K9, NFKB1, NFKBIA, PIK3CG, TRGV8

IL-17 signaling

1.32E−05

AKT3, CCL20, CXCL1, CXCL3, DEFB1, DEFB105A/DEFB105B, FOS, IL1B, MAP2K6, MUC5AC, NFKB1, PIK3CG, TGFB1, TNFSF13, TRAF3IP2, TRAF5, VEGFD