Table 4 Description of GWAS statistic included in present study

Benyamin et al. (the 2014 datasets)

25352340

Serum ferritin

Mean, SD

Age, principal component scores and other study specific covariates, for each sex separately, adjustments for each cohort were available in the supplementary of original article

23,986 (Discovery) + 24,986 (Replication)

Genetics of Iron Status Consortium, the Discovery cohorts were composed of 11 cohorts in 9 participating centers, and 8 additional cohorts for the Replication cohorts

European ancestry

Males and Females

25352340

Serum iron

25352340

Serum transferrin

25352340

Transferrin Saturation

Bell et al. (the 2021 datasets)

33536631

Serum ferritin

Rank-based inverse normal transformed SD

Adjusted for age using a generalized additive model. Additionally, for UK cohort the biomarkers were adjusted for menopausal status, ABO blood group, BMI, smoking levels, alcohol levels and iron supplementation status

246,139

Ice land (deCODE genetics), UK (INTERVAL study) and Denmark (Danish Blood Donor Study)

European ancestry

Males and Females

33536631

Serum iron

163,551

33536631

Iron binding capacity

135,430

33536631

Transferrin saturation

131,471

Liu et al.

34128465

Liver iron content

Mean, SD

Age at imaging visit, age squared, sex, imaging center, scan date, scan time, and genotyping batch

11,069

UK Biobank

European ancestry

Males and females

34128465

Pancreas iron content

Mean, SD

5,525

McCartney et al.

34187551

GrimAA

Mean, SD

Adjustments for each cohort were available in the supplementary of original article

34,710

29 studies from UK (n = 9), USA (n = 8), Netherlands (n = 3), Finland (n = 2), and Australia (n = 1), Denmark (n = 1), Estonia (n = 1), Germany (n = 1), Italy (n = 1), Sweden (n = 1) and Switzerland (n = 1)

European ancestry

Males and females

34187551

HannumAA

34,710

34187551

Horvath (IEAA)

34,710

34187551

PhenoAA

34,710