Table 3 Sensitivity analyses of organic iron content with epigenetic aging accelerations
Exposure | Outcome | Weighted median | MR-egger regression | Heterogeneitya | MR-PRESSO outlier detectb | Pleiotropyc | |||
|---|---|---|---|---|---|---|---|---|---|
Beta (95% CI) | P value | Beta (95% CI) | P value | Beta (95% CI) | P Value | ||||
Liver iron content | Grim | 0.28 (0.05, 0.50) | 1.63E−02 | 0.27 (− 0.03, 0.56) | 1.12E−01 | I2 = 0%; Cochrane Q = 8; P = 0.538 | No significant outliers | Intercept = -0.003; P = 0.892 | |
Liver iron content | Hannum | 0.35 (0.13, 0.57) | 2.01E−03 | 0.42 (0.08, 0.76) | 3.97E−02 | I2 = 21.1%; Cochrane Q = 11; P = 0.249 | No significant outliers | Intercept = -0.014; P = 0.598 | |
Liver iron content | IE | 0.39 (0.16, 0.62) | 8.75E−04 | 0.32 (0.02, 0.62) | 7.22E−02 | I2 = 0%; Cochrane Q = 7; P = 0.520 | No significant outliers | Intercept = 0.019; P = 0.421 | |
Liver iron content | Pheno | 0.39 (0.09, 0.69) | 1.19E−02 | 0.21 (− 0.36, 0.77) | 4.95E−01 | I2 = 58.5%; Cochrane Q = 22; P = 0.010 | 0.43 (0.12, 0.74) | 2.54E−02 | Intercept = 0.052; P = 0.241 |
Pancreas iron content | Grim | 0.11 (− 0.35, 0.57) | 6.35E−01 | 0.57 (− 0.29, 1.43) | 2.10E−01 | I2 = 4.2%; Cochrane Q = 22; P = 0.404 | No significant outliers | Intercept = -0.029; P = 0.316 | |
Pancreas iron content | Hannum | 0.08 (− 0.42, 0.58) | 7.46E−01 | 0.50 (− 0.41, 1.41) | 2.96E−01 | I2 = 9.9%; Cochrane Q = 23; P = 0.328 | No significant outliers | Intercept = -0.030; P = 0.328 | |
Pancreas iron content | IE | 0.35 (− 0.30, 1.00) | 2.87E−01 | 0.45 (− 0.84, 1.75) | 5.00E−01 | I2 = 16.4%; Cochrane Q = 25; P = 0.242 | No significant outliers | Intercept = -0.004; P = 0.931 | |
Pancreas iron content | Pheno | 0.18 (− 0.29, 0.66) | 4.48E−01 | 0.35 (− 0.51, 1.21) | 4.35E−01 | I2 = 0%; Cochrane Q = 17; P = 0.715 | No significant outliers | Intercept = -0.011; P = 0.701 | |