Table 2 Results of mediation analysis using two-step MR
Exposures | Mediators | Outcomes | Total effect | Direct effect A | Direct effect B | Mediation effect | p | Mediated proportion (%) |
|---|---|---|---|---|---|---|---|---|
Effect size (95% CI) | Effect size (95% CI) | Effect size (95% CI) | Effect size (95% CI) | Effect size (95% CI) | ||||
AFB | BMI | PhenoAge | − 0.074 (− 0.252, 0.103) | − 0.104 (− 0.134, − 0.073) | 0.528 (0.290, 0.767) | − 0.055 (− 0.119, 0.009) | 0.392 | / |
GrimAge | − 0.210 (− 0.350, − 0.070) | − 0.104 (− 0.134, − 0.073) | 0.595 (0.409, 0.782) | 0.062 (0.005, 0.119) | 0.274 | 29.5 (2.3,56.6) | ||
AFB | HannumAge | − 0.429 (− 0.781, − 0.077) | 2.046 (1.901, 2.191) | − 0.175 (− 0.336, − 0.014) | 0.358 (0.206, 0.510) | 0.018 | 83.4 (48.0,118.9) | |
AFS | GrimAge | − 1.136 (− 1.508, − 0.765) | 2.046 (1.901, 2.191) | − 0.210 (− 0.350, − 0.070) | 0.430 (0.278, 0.582) | 0.005 | 37.8 (24.5,51.2) | |
BMI | PhenoAge | − 0.571 (− 1.006, − 0.136) | − 0.338 (− 0.427, − 0.249) | 0.528 (0.290, 0.767) | 0.178 (0.112, 0.244) | 0.007 | 31.17 (19.6,42.7) | |
GrimAge | − 1.136 (− 1.508, − 0.765) | − 0.338 (− 0.427, − 0.249) | 0.595 (0.409, 0.782) | − 0.201 (− 0.260, − 0.142) | 5.97E − 04 | 17.7 (12.5,22.9) | ||
AAM | AFB | GrimAge | − 0.215 (− 0.433, − 0.003) | 0.205 (1.106, 1.362) | − 0.210 (− 0.350, − 0.070) | 0.043 (0.024, 0.062) | 0.020 | 20 (11.2,28.8) |
AFS | GrimAge | − 0.215 (− 0.433, − 0.003) | 0.093 (0.061, 0.125) | − 1.136 (− 1.508, − 0.765) | − 0.106 (− 0.321, 0.109) | 0.623 | / | |
BMI | GrimAge | − 0.215 (− 0.433, − 0.003) | − 0.156 (0.801, 0.915) | 0.595 (0.409, 0.782) | − 0.093 (− 0.150, − 0.036) | 0.101 | 43.3 (16.7,69.8) |