Table 1 Results of MR analysis for selected exposures on possible mediators and MR analysis for possible mediator on selected outcomes
Exposure | Outcome | β (95% CI) | p | SE |
|---|---|---|---|---|
AFB | BMI | − 0.104 (− 0.134, − 0.073) | 3.50E−11 | 0.016 |
AFS | AFB | 2.046 (1.901, 2.191) | 6.75E−169 | 7.39E−02 |
BMI | − 0.338 (− 0.427, − 0.249) | 1.15E−13 | 0.046 | |
AAM | AFB | 0.205 (0.100, 0.309) | 1.19E−04 | 5.32E−02 |
AFS | 0.093 (0.061, 0.125) | 1.18E−08 | 1.63E−02 | |
BMI | − 0.156 (− 0.222, − 0.089) | 4.50E−06 | 3.39E−02 | |
BMI | HannumAge | 0.163 (− 0.021, 0.348) | 0.083 | 9.41E−02 |
PhenoAge | 0.528 (0.290, 0.767) | 1.37E−05 | 1.22E−01 | |
GrimAge | 0.595 (0.409, 0.782) | 3.66E−10 | 9.50E−02 |