Table 2 Summary results of genome-wide CpGs associated with albuterol exposure in nasal cells
From: Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
CpG | Chr | Position* | Gene | Discovery | Validation | ||||
|---|---|---|---|---|---|---|---|---|---|
ΔDNAm (%) | logFC | p-value | logFC | p-value | FDR | ||||
cg10290200 | 7 | 128841241 | FLNC | − 3.4 | − 0.397 | 2.76 × 10–18 | − 0.131 | 0.328 | 0.620 |
cg00483640 | 6 | 2623249 | MYLK4-LINC01600 | − 4.9 | − 0.358 | 2.06 × 10–17 | − 0.321 | 0.003 | 0.021 |
cg15833511 | 20 | 36628395 | SLA2 | − 15.3 | − 0.318 | 2.92 × 10–16 | − − 0.169 | 0.102 | 0.348 |
cg24254891 | 22 | 39999311 | FAM83F | − 15.6 | − 0.290 | 4.16 × 10–13 | − 0.015 | 0.906 | 0.963 |
cg12510044 | 22 | 21761184 | MAPK1 | − 9.1 | − 0.277 | 9.56 × 10–13 | − 0.151 | 0.152 | 0.368 |
cg02424494 | 2 | 238291487 | PER2 | − 2.3 | − 0.219 | 1.49 × 10–11 | − 0.202 | 0.031 | 0.133 |
cg03629778 | 7 | 130051485 | ZC3HC1 | − 10.1 | − 0.203 | 2.43 × 10–11 | 0.039 | 0.701 | 0.851 |
cg05673431 | 17 | 27544478 | KSR1 | − 2.4 | − 0.175 | 4.46 × 10–11 | − 0.240 | 0.004 | 0.021 |
cg11023970 | 10 | 6295886 | PFKFB3 | 4.4 | 0.181 | 1.55 × 10–10 | 0.052 | 0.619 | 0.809 |
cg03956296 | 2 | 39724059 | THUMPD2 | − 17.7 | − 0.475 | 1.66 × 10–9 | NA | NA | NA |
cg23032799 | 11 | 46274563 | CREB3L1 | − 6.5 | − 0.177 | 3.48 × 10–9 | − 0.264 | 1.53 × 10–4 | 0.003 |
cg08161666 | 11 | 13013350 | ARNTL | − 16.8 | − 0.361 | 4.20 × 10–9 | − 0.318 | 0.125 | 0.353 |
cg10310427 | 6 | 30749208 | IER3 | − 8.2 | − 0.169 | 7.50 × 10–9 | − 0.004 | 0.964 | 0.964 |
cg16769649 | 6 | 47358617 | TNFRSF21 | − 8.4 | − 0.267 | 9.55 × 10–9 | NA | NA | NA |
cg26162522 | 1 | 56571443 | PPAP2B | − 3.5 | − 0.202 | 1.52 × 10–8 | NA | NA | NA |
cg16032470 | 20 | 33230393 | BPIFA1 | − 8.8 | − 0.175 | 1.78 × 10–8 | NA | NA | NA |
cg03068616 | 6 | 6678265 | LY86 | − 12.6 | − 0.271 | 1.97 × 10–8 | − 0.174 | 0.202 | 0.429 |
cg16519100 | 15 | 83200514 | HDGFRP3 | 23.5 | 0.271 | 2.66 × 10–8 | − 0.121 | 0.478 | 0.734 |
cg22208174 | 9 | 106880861 | ZNF462 | − 7.6 | − 0.239 | 2.81 × 10–8 | NA | NA | NA |
cg12845391 | 6 | 137224161 | IFNGR1 | − 4.4 | − 0.129 | 3.38 × 10–8 | − 0.043 | 0.518 | 0.734 |
cg12845808 | 5 | 141959039 | PCDH12 | − 7.3 | − 0.109 | 4.54 × 10–8 | − 0.012 | 0.866 | 0.963 |
cg03946667 | 5 | 136058672 | TGFBI | − 5.2 | − 0.147 | 4.63 × 10–8 | − 0.052 | 0.505 | 0.734 |