Fig. 6

Schematic representation of the potential implementation of a blood-based test in CRC screening. To target different sample preferences and improve participation rates, a blood test could be offered to individuals refusing FIT (left arm). In combination with FIT, the blood test may improve selection for follow-up colonoscopy after a positive FIT (right arm). A FIT test would be offered every two years to individuals rejecting both the FIT and the blood test, and to individuals with a previous negative result in either FIT or blood-based test