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Table 2 Location of major DNA methylation difference between control and maternal separation tissue

From: A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain

Significant Cytosine (rn6)

Location

Distance to CGI (bp)

Nearest CGI

TFBS motifs (±10 bp)

Transfac include

Mouse Syntenic Loci Regulatory Prediction (CNS)

chr20:8,063,895

CGI shore

1,741

chr20:8,061,330–8,062,154

TFCP2

Quiescent/Polycomb Repressed/Poised Enhancer

chr20:8,096,364

CGI shore

935

chr20:8,097,299–8,097,607

EGR

Active Promoter/Polycomb Repressed (Bivalent)

  1. Includes (Left to Right): Location of Cytosine (rn6 build); Location annotation; Distance to nearest CpG Island (CGI); Co-ordinates of nearest CGI; Highlighted enriched Transcription Factor Binding Site motifs in ± 10 bp window centred on CpG via Transfac (TRAP analysis); and observed Chromatin Segmentation signature in the syntenic Mouse location (GRCm38/mm10, via LiftOver) in developmental central neural tissue [27])
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Clinical Epigenetics

ISSN: 1868-7083

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