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Table 1 Location of significant DNA methylation difference between tissue from animals with ankle joint inflammation and nerve injury

From: A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain

Significant Cytosine (rn6)

Location

Distance to CGI (bp)

Nearest CGI

TFBS motifs (±10 bp)

Transfac include

Mouse Syntenic Loci Regulatory Prediction (CNS)

chr20:8,059,052

Intronic

CGI shelf

2,278

chr20:8,061,330–8,062,154

E2F1

Poised Enhancer/Quiescent Gene

chr20:8,059,072

Intronic

CGI shelf

2,258

chr20:8,061,330–8,062,154

AP1

Poised Enhancer/Quiescent Gene

  1. Includes (Left to Right): Location of Cytosine (rn6 build); Location annotation; Distance to nearest CpG Island (CGI); Co-ordinates of nearest CGI; Highlighted enriched Transcription Factor Binding Site motifs in ± 10 bp window centred on CpG via Transfac (TRAP analysis [24]; and observed Chromatin Segmentation signature in the syntenic Mouse location (GRCm38/mm10, via LiftOver) in developmental central neural tissue [27])
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Clinical Epigenetics

ISSN: 1868-7083

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