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Fig. 5 | Clinical Epigenetics

Fig. 5

From: A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism

Fig. 5

Analysis of retinoid metabolism and upstream regulator. A Graph of the STRING software interaction analysis. Analysis of the interaction and upstream regulation of the 3 main retinoid-related genes (Lrat, Rpe65, and Rdh5) using STRING software highlight the involvement of Rarα in the regulation of Lrat. B Schematic representation of the retinoid metabolism in the retina, emphasizing the three main enzymes involved in the cycle. C Quantification of mRNA levels for Lrat, Rpe65, and Rdh5 genes in retinal tissue using RT-qPCR. D Analysis of retinoid metabolites in retinal tissue using LC/MSMS approach. E Epigenetic analysis displaying the beta values of significantly differentially methylated CpGs positions in the promoter of Rarα gene in Mtr-cKO mice compared to wild type. Data represent means ± SEM. Statistical analysis was performed using the Student t test (*P < 0.05, **P < 0.01, ***P < 0.001). N = 3 to 5 mice per group

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Clinical Epigenetics

ISSN: 1868-7083

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