Table 3 The relative proportions of CpGs which are hypomethylated in both discovery (q < 0.05) and validation (p < 0.05) cohorts, by genomic loci
From: Degradation of methylation signals in cryopreserved DNA
Genomic loci | Proportion tested (%) | Proportion validated (%) | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|
Shelf, North | 30056/827646 (3.6%) | 19/692 (2.7%) | 0.7 (0.4–1.2) | 0.262 |
Shore, North | 80282/827646 (9.7%) | 114/692 (16.5%) | 1.8 (1.5–2.2)* | 2.6e-8 |
Island | 157284/827646 (19.0%) | 100/692 (14.5%) | 0.7 (0.6–0.9) | 1.9e-3 |
Shore, South | 68669/827646 (8.3%) | 101/692 (14.6%) | 1.9 (1.5–2.3) | 3.8e-8 |
Shelf, South | 27971/827646 (3.4%) | 22/692 (3.2%) | 0.9 (0.6–1.4) | 0.916 |
Open sea | 463384/827646 (56.0%) | 336/692 (48.6%) | 0.7 (0.6–0.9) | 9.1e-5 |