Table 2 Results for the robust linear regression for mean global methylation. The coefficient estimates for storage durations and age represent the change in methylation M-value per year

Intercept

0.29

(0.22–0.37)

7.5e − 12*

4.58

(3.59 – 5.58)

4.6e − 15

Storage as DNA

9.64e-03

(− 1.09e − 02–3.02e − 02)

0.360

8.57e − 03

(− 7.29e − 03–2.44e − 02)

0.292

Storage as buffy coat

 − 2.52e − 06

(− 3.52e − 04–3.47e − 04)

0.989

Age

2.31e − 07

(− 2.17e − 06–2.63e − 06)

0.851

CD8 + T

 − 4.28

(− 5.29– − 3.27)

1.8e − 13

CD4 + T

 − 4.15

(− 5.20– − 3.09)

5.4e − 12

NK cell

 − 4.42

(− 5.40– − 3.45)

9.1e − 15

B cell

 − 4.24

(− 5.25– − 3.23)

3.3e − 13

Monocytes

 − 4.48

(− 5.55– − 3.42)

2.9e − 13

Granulocytes

 − 4.34

(− 5.35– − 3.33)

1.3e − 13

Model AIC

 − 420.3

 − 488.8

Model BIC

 − 411.8

 − 457.6

Intercept

0.28

(0.25–0.31)

2.8e − 36

3.89

(2.80–4.98)

1.5e − 10

Storage as DNA

0.02

(0.00–0.03)

0.030

9.36e − 03

(− 3.01e − 03–2.17e − 02)

0.140

Age

1.42e − 06

(-1.64e − 06–4.48e − 06)

0.366

CD8 + T

 − 3.65

(− 4.76– − 2.55)

2.0e − 09

CD4 + T

 − 3.47

(− 4.61– − 2.32)

2.5e − 08

NK cell

 − 3.60

(− 4.68– − 2.51)

1.6e − 09

B cell

 − 3.38

(− 4.51– − 2.25)

4.0e − 08

Monocytes

 − 3.48

(− 4.63– − 2.33)

2.7e − 08

Granulocytes

 − 3.70

(− 4.80– − 2.60)

1.0e − 09

Model AIC

 − 494.7

 − 558.0

Model BIC

 − 486.0

 − 528.9