Fig. 3

Aging-associated DNA methylation (DNAm) events identified in the α-irradiated lung fibroblasts. These events are based on the DNAm clock from Horvath [33] and on the PhenoAge DNAm clock from Levine et al. [34]. A Number of differentially methylated regions (DMRs) from the α-irradiated fibroblasts whose neighboring genes were associated with aging as established by the two selected DNAm clocks. B Table displaying the enrichment analysis results of the aging-associated genes whose DNAm levels were altered in the α-irradiated fibroblasts, computed using the cumulative distribution function of the hypergeometric equation from [49]. C Top 5 functional classification of the genes affected by the aging-associated DMRs using Ingenuity Pathway Analysis. Abbreviations: SF, single-fraction; MF, multi-fraction; TSS, transcription start site; TTS, transcription termination site; 3’ UTR, 3’ untranslated region; and 5’ UTR, 5’ untranslated region