Table 1 Microbial metabolites-mediated epigenetic regulation in IBD
From: Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Study | Microbial metabolites | Histone modifying enzymes/histone markers | Regulatory molecules | Effects on IBD |
|---|---|---|---|---|
Kelly et al. [34] | N/A | H3K4me3 | N/A | Correlate with intestinal inflammation |
Lund et al. [35] | Butyrate | H4 acetylation | N/A | Affect energy homeostasis |
Yang et al. [36] | Butyrate | HDAC | GPR41-HIF1α/AhR-IL-22 | Maintain intestinal homeostasis |
Wu et al. [39] | InsP3 | HDAC3 | N/A | Promote intestinal epithelial cell proliferation and repair |
Gao et al. [41] | Butyrate | HDAC3 | p-GSK-3β, β-catenin, Nrf2, NF-κB | Reverse small intestinal mucosal injury, inflammation response, and oxidative stress |
Li et al. [42] | Butyrate | HDAC | N/A | Ameliorate mucosal inflammation |
Dupraz et al. [43] | Propionate | HDAC | IL-17 | Inhibit intestinal inflammation |
Jugder et al. [47] | Acetate | Tip60 | IMD signaling | Control host metabolism and innate immunity in the gut |
Deng et al. [48] | p40 | Setd1β-mediated H3K4me1/3 | TGFβ | Protect the gut against inflammation |