Fig. 2

A schematic diagram showing different histone-modifying enzymes involved in the progression of CRC indicated by dysplasia (left) and invasive colon cancer (right). Histone-modifying enzymes are categorized into 4 groups: methyltransferase, demethylase, acetyltransferase, and deacetylase. From the left to the right, different histone-modifying enzymes regulate different signaling pathways leading to CRC progression but are not associated with the progression process. This figure is adapted from “Colon Cancer Progression” by BioRender.com (2023). Retrieved from https://app.biorender.com/biorender-templates