Table 4 Effects of prenatal exposure to famine on genome-wide DNA methylation and mental disorders
References | Cohort | Sample description of groups with prenatal or non-exposure | Assessment of symptoms of sychopathology | Chromosome | Gene | No CpG | DNA methylation analysis from blood | Main results |
|---|---|---|---|---|---|---|---|---|
Boks et al. [75] | Chinese Famine*a | Prenatally exposed controls N = 25, ♀ = 15, mean age 50 | Non-standardized diagnosis accordingto DSM IV criteria | chr6: 291687–293285 | DUSP22 | 10 | Infinium HumanMethylation 450BeadChip | Hypermethylation of DUSP22** in prenatal exposed SZ patients compared to all other groups |
Prenatally exposed SZ patients N = 23, ♀ = 5, mean age 50 | ||||||||
Non-exposed controls N = 54, ♀ = 33, mean age 47 | ||||||||
Non-exposed SZ patients N = 51, ♀ = 23, mean age 47 |  |