Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics

Table 1 Clinical features of FDR and CTRL individuals

Phenotypes	FDR subjects	CTRL subjects	p value
N (female/male)	9 (5/4)	11 (6/5)	> 0.9999
Age, years	42.33 ± 8.72	38.73 ± 7.76	0.3398
BMI, Kg/m²	25.36 ± 1.53	24.46 ± 2.30	0.2221
Fat percent, %	26.89 ± 7.28	23.96 ± 6.42	0.5516
Waist-to-hip ratio (WHR)	0.90 ± 0.05	0.81 ± 0.07	0.0021
FFM, kg	57.13 ± 11.74	57.08 ± 10.43	0.9262
Subcutaneous adipocyte size, μm	100.24 ± 5.08	89.42 ± 6.26	0.0005
f-insulin, pmol/L	60.10 ± 22.71	35.36 ± 12.98	0.0091
fb-glucose, mmol/L	4.82 ± 0.42	4.36 ± 0.40	0.007
OGTT p-glucose 2 h, mmol/L	6.56 ± 1.71	4.84 ± 1.24	0.0346
GIR/bw, mg/kg/min	7.93 ± 1.70	11.50 ± 2.51	0.0023

All data are expressed as mean ± SD, and statistical significance between the two groups was determined by Mann–Whitney test for continuous variables and Fisher's exact test for categorical variable
BMI body mass index, CTRL subjects with no diabetes familiarity (controls), f-insulin fasting insulin, fb-glucose fasting blood-glucose, FDR first‐degree relatives of T2D subjects, FFM fat free mass, GIR/bw glucose infusion rate/body weight, OGTT p-glucose plasma glucose levels during oral glucose tolerance test

ISSN: 1868-7083