Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk

Clinical Epigenetics

Table 5 Comparison of cumulative methylation rates at all CpG sites and significant CpG sites

Gene	Cases (n = 102) Mean ± SD	Controls (n = 102) Mean ± SD	Z	P
Model 1 (all CpG sites)
VDR	0.46 ± 0.11	0.46±0.07	− 1.45	0.15
CYP24A1	1.85 ± 0.45	1.83±0.34	− 0.32	0.75
CYP27B1	0.54 ± 0.18	0.54±0.14	− 0.58	0.56
CYP2R1	0.28 ± 0.04	0.30±0.16	− 0.76	0.45
Model 2 (significant CpG sites)
VDR	0.06 ± 0.03	0.07 ± 0.02	− 3.58	0.001
CYP24A1	0.05 ± 0.02	0.06 ± 0.02	− 3.25	< 0.001

The data of cumulative methylation rates at all CpG sites and significant CpG sites are expressed as Mean ± SD

ISSN: 1868-7083