Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk

Clinical Epigenetics

Table 4 Methylation rates of significant CpG sites between the cases and the controls

CpG site	Gene	Position	Cases (n = 102) Mean ± SD	Controls (n = 102) Mean ± SD	P
58	VDR	12: 47,905,454	0.018 ± 0.013	0.020 ± 0.008	0.02
106	VDR	12: 47,905,502	0.038 ± 0.017	0.040 ± 0.012	0.02
110	VDR	12: 47,905,506	0.012 ± 0.008	0.014 ± 0.007	0.02
102	CYP24A1	20: 54,174,368	0.018 ± 0.011	0.021 ± 0.011	0.03
200	CYP24A1	20: 54,174,270	0.011 ± 0.009	0.014 ± 0.009	0.007
41	CYP24A1	20: 54,173,555	0.022 ± 0.008	0.023 ± 0.007	0.047
53	CYP24A1	20: 54,172,987	0.050 ± 0.024	0.040 ± 0.011	0.02
90	CYP2R1	11: 14,891,718	0.017 ± 0.005	0.019 ± 0.005	0.04

The data of methylation rates of significant CpG sites are expressed as Mean ± SD

ISSN: 1868-7083