Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk

Clinical Epigenetics

Table 1 Details of the CpG islands of VDR, CYP24A1, CYP27B1 and CYP2R1

Gene	Fragment	TSS	Start	End	Length	Target Strand	Distance 2TSS	Number of CpG sites
VDR	VDR_1	47,904,994	47,905,397	47,905,564	168	+	− 403	15
	VDR_2	47,904,994	47,904,776	47,905,043	268	+	218	22
CYP24A1	CYP24A1_1	54,173,986	54,174,469	54,174,217	253	−	− 483	29
	CYP24A1_2	54,173,986	54,173,595	54,173,365	231	−	391	17
	CYP24A1_3	54,173,986	54,173,176	54,173,013	164	−	810	12
	CYP24A1_4	54,173,986	54,173,039	54,172,868	172	−	947	13
CYP27B1	CYP27B1	57,767,078	57,766,171	57,765,967	205	−	907	17
CYP2R1	CYP2R1_1	14,892,205	14,891,629	14,891,787	159	+	576	15
	CYP2R1_2	14,892,205	14,891,347	14,891,079	269	−	858	13

Start, The starting position of the product on the reference genome; TSS, The mRNA transcription start site; End, The end position of the product on the reference genome; Length, the product length; Target strand, The product orientation; Distance 2TSS, The distance from the product to the TSS

ISSN: 1868-7083