Skip to main content

Table 5 Associations between maternal methyl nutrient intake or blood levels and placental DNMT expression or cord blood SAM/SAH ratios

From: Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus

 

DNMT1

DNMT3A

Cord SAM/SAH

r

p

R

p

r

p

Intake

 Choline

0.002

0.95

0.074

0.63

0.013

0.91

 Betaine

− 0.034

0.88

0.035

0.86

0.13

0.6

 Vitamin B12

− 0.28

0.055

− 0.17

0.25

− 0.19

0.17

 Folate

− 0.07

0.63

− 0.038

0.8

0.087

0.63

 Dietary methylation score

− 0.19

0.2

− 0.079

0.55

0.018

0.91

Blood metabolite

 Choline

0.079

0.48

− 0.064

0.78

0.44

0.016

 Betaine

0.15

0.31

0.053

0.73

0.089

0.39

 Holotranscobalamin

0.02

0.89

0.046

0.78

0.045

0.56

 Folate

− 0.38

0.015

− 0.32

0.032

− 0.079

0.58

 Homocysteine

0.092

0.53

0.008

0.93

0.14

0.47

  1. n = 21 for the GDM group and n = 26 for the non-GDM group. Analyzed with generalized linear model adjusted for GDM status, GDM × nutrient intake/blood status interaction, total energy intake, and fetal covariates including sex of neonate, gestational age at birth, and mode of delivery. The correlation coefficient (r) was calculated using partial correlation controlling for the variables mentioned above. DNMT DNA methyltransferase, SAM S-adenosylmethionine, SAH S-adenosylhomocysteine
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us