Skip to main content

Table 4 Associations between maternal methyl nutrient intake or blood levels and CRH promoter DNA methylation in the placenta and cord blood

From: Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus

 

Placenta CRH methylation

Cord CRH methylation

r

p

r

p

Intake

 Choline

0.011

0.4

0.13

0.007

 Betaine

0.067

0.79

− 0.003

0.74

 Vitamin B12

0.082

0.32

− 0.004

0.39

 Folate

0.094

0.21

0.063

0.55

 Dietary methylation score

0.092

0.61

0.047

0.22

Blood metabolite

 Choline

0.001

0.91

− 0.018

0.44

 Betaine

0.15

0.067

0.045

0.3

 Holotranscobalamin

− 0.061

0.29

0.074

0.04

 Folate

− 0.047

0.67

0.021

0.6

 Homocysteine

− 0.09

0.62

0.08

0.39

  1. n = 21 for the GDM group and n = 26 for the non-GDM group. Analyzed with generalized mixed model adjusted for GDM status, GDM × nutrient intake/blood status interaction, total energy intake, and fetal covariates including sex of neonate, gestational age at birth, and mode of delivery. The correlation coefficient (r) was calculated using partial correlation controlling for the variables mentioned above. CRH corticotropin-releasing hormone
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us