Skip to main content

Table 3 Associations between maternal methyl nutrient intake or blood levels and IGF2 DMR0 DNA methylation in the placenta and cord blood

From: Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus

 

Placenta IGF2 DMR0

Cord IGF2 DMR0

r

p

r

p

Intake

 Choline

0.004

0.93

0.11

0.53

 Betaine

− 0.11

0.89

− 0.13

0.049

 Vitamin B12

  GDM

0.1

0.17

0.001

0.43

  Non-GDM

  

0.21

0.12

 Folate

  GDM

− 0.011

0.39

− 0.22

0.18

  Non-GDM

  

0.077

0.9

 Dietary methylation score

0.031

0.71

0.002

0.95

Blood metabolite

 Choline

0.017

0.66

0.06

0.45

 Betaine

0.063

0.19

− 0.038

0.33

 Holotranscobalamin

0.012

0.59

0.037

0.63

 Folate

− 0.065

0.034

0.009

0.59

 Homocysteine

0.051

0.41

0.075

0.73

  1. n = 21 for the GDM group and n = 26 for the non-GDM group. Analyzed with generalized linear mixed model adjusted for GDM status, GDM × nutrient intake/blood status interaction, total energy intake, and fetal covariates including sex of neonate, gestational age at birth, and mode of delivery. The correlation coefficient (r) was calculated using partial correlation controlling for the variables mentioned above. DMR0 differentially methylated region 0, IGF2 insulin-like growth factor 2
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us