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Table 2 Associations between maternal methyl nutrient intake or blood levels and global DNA methylation in the placenta and cord blood

From: Associations between nutrients in one-carbon metabolism and fetal DNA methylation in pregnancies with or without gestational diabetes mellitus

 

Placenta

Cord blood

r

p

r

p

Intake

 Choline

− 0.04

0.8

− 0.06

0.58

 Betaine

  GDM

0.17

0.66

− 0.07

0.52

  Non-GDM

− 0.31

0.16

  

 Vitamin B12

  GDM

− 0.006

0.87

0.17

0.29

  Non-GDM

0.31

0.06

  

 Folate

− 0.22

0.1

0.01

0.96

 Dietary methylation score

  GDM

− 0.11

0.41

0.04

0.85

  Non-GDM

0.24

0.18

  

Blood metabolite

 Choline

− 0.42

0.47

0.16

0.93

 Betaine

− 0.47

0.55

0.01

0.96

 Holotranscobalamin

− 0.25

0.007

0.05

0.99

 Folate

0.09

0.47

0.07

0.73

 Homocysteine

  GDM

− 0.22

 < 0.01

0.24

0.62

  non-GDM

  

0.49

0.01

  1. n = 21 for the GDM group and n = 26 for the non-GDM group. Analyzed with generalized linear model adjusted for GDM status, GDM × nutrient intake/status interaction, total energy intake, and fetal covariates including sex of neonate, gestational age at birth, and mode of delivery. The correlation coefficient (r) was calculated using partial correlation controlling for the variables mentioned above
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Clinical Epigenetics

ISSN: 1868-7083

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