Fig. 2

Boxplots for CpG sites showing statistically significant differences in DNA methylation (DNAm) by acetaminophen detection. The y-axis shows DNA methylation levels ranging from 0 to 1 for 0–100% methylated. Blue boxes and dots denote DNAm levels for participants in the detectable acetaminophen group (n = 96). Pink boxes and dots denote DNAm levels of participants with no detectable acetaminophen (n = 474). The boxplots are arranged from left to right and top to bottom according to their genomic physical position, from upstream (5’) to downstream (3’). Red rectangles mark the differentially methylated CpGs that pass an FDR < 0.05 significance level. Blue rectangles mark the significantly variably methylated CpGs (FDR < 0.05). Purple rectangle marks the CpG with FDR < 0.05 in both the tests