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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort

Fig. 1

Pathways for acetaminophen metabolism. Acetaminophen metabolizes in liver through three main pathways: glucuronidation (shown in purple), sulfation (shown in green) and phase I oxidation (shown in red). Cytochrome P450 2E1 (CYP2E1) is the primary enzyme responsible for the bioconversion of acetaminophen to N-acetyl-p-benzoquinone imine (NAPQI) through the Phase I oxidation pathway. The chemical structures of the metabolites were obtained from The Human Metabolome Database (HMDB) (http://hmdb.ca)

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Clinical Epigenetics

ISSN: 1868-7083

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