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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Abnormal DNA methylation analysis of leucine-rich glioma-inactivated 1 antibody encephalitis reveals novel methylation-driven genes related to prognostic and clinical features

Fig. 5

Methylation-driven cytokines/chemokines and ICMs in LGI1 encephalitis. A A heatmap representing discrepant serum protein expression of 15 methylation-driven cytokines/chemokines and ICMs in LGI1 encephalitis cohort compared with that in control group. B The multiple DMRs in gene body of 8 genes in LGI1 encephalitis cohort compared with that in control. C The methylation changes in promoter of 14 genes in LGI1 encephalitis cohort compared with normal donors. D Validation of methylation changes of 5 methylation-driven genes by bisulfite pyrosequencing using 5 encephalitis samples vs. 5 normal samples. E The external database GSE132866 showing differential DNA methylation level in promoter of TNFRSF1A, ICAM1, IL7, IL2 and IL-12 P40 in AE encephalitis cohort compared with normal donors. F PCR analysis of expression level of 5 gene in Fig. 5D between the patients with LGI1 encephalitis and normal donors. LGI1-E LGI1 encephalitis; ND normal donor; AE autoimmune encephalitis. Data are means ± SD of three experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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