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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children

Fig. 6

H3K9me3 regions upregulated in 18-week-old infants overlap active regulatory elements misregulated in 1-year-old stunted children. a Bar plot showing percentage of all H3K4me3 and H3K27ac regions identified in 18-week- and one-year-old children that overlap H3K9me3 regions identified in 18-week-old infants. The overlaps were counted separately for upregulated (red) vs. downregulated (blue) regions at a given age in stunting. b Bar plot as in (a) only showing overlaps with regions that were significantly different in stunted children. c Explanatory illustration for panel (d) showing different overlap scenarios. d The plots show the proportions of H3K9me3 regions that overlap significantly downregulated H3K27ac (left) or significantly upregulated H3K4me3 (right) in one-year-old children (x-axis) versus the proportions of these H3K27ac and H3K4me3 regions that overlap with H3K9me3 (y-axis). Color coding indicates the percentage of regions falling into a given bin. The total number of overlapping regions for each category is indicated above the individual color bars

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Clinical Epigenetics

ISSN: 1868-7083

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