Fig. 2
H3K9me3 profiles are globally correlated with negative growth change between birth and one year. a Average H3K9me3 profiles within peaks and 2 kb regions surrounding peaks. Each line represents an average profile of a child color coded by the child’s ΔHAZ (birth:1yr) score. The average profiles were normalized by drosophila spike-in normalization factors. b Spearman’s correlation coefficients (rho) between average normalized profile values from peak centers in (a) and a given measurement indicated on x axis. c PCA plot of H3K9me3 read counts in identified peaks. The numbers in brackets indicate variance explained by a given principal component. d Spearman’s correlation coefficients (rho) between PC1 and measurements indicated on x-axis. e Linear fit between ΔHAZ (birth:1yr) score and percentage of reads mapped to the Drosophila melanogaster genome. The relationship is significant (p-value = 0.021). Degrees of freedom = 13, adjusted R2 = 0.296