Table 4 Season of birth associated differentially methylated regions (DMRs) at birth in cohorts from latitudes ≥ 50°N
Season of birtha | CHR | Region (hg19) | CpGs in the region | Šidák p valueb | Minimum p valuec | Gene | Gene group |
|---|---|---|---|---|---|---|---|
Winter | 1 | 203733946–203734584 | 6 | 7.2 × 10−8 | 1.7 × 10−7 | LAX1 | TSS, intron, 5′UTR, cds; exon |
6 | 170571118–170572041 | 10 | 1.1 × 10−5 | 1.1 × 10−6 | LOC154449 | nc_intron, nc_exon | |
7 | 1753371–1753934 | 7 | 1.4 × 10−5 | 9.0 × 10−6 | ELFN1 | intron, 5′UTR | |
3 | 122712113–122712742 | 4 | 3.7 × 10−5 | 2.1 × 10−5 | SEMA5B | TSS, exon, 5′UTR; intron, nc_intron | |
19 | 35629676–35630499 | 10 | 4.2 × 10−5 | 2.1 × 10−5 | FXYD1 | TSS, intron, exon, 5′UTR | |
17 | 72442903–72443426 | 6 | 1.1 × 10−4 | 3.5 × 10−5 | GPRC5C | intron, 3′UTR, cds | |
11 | 299365–300797 | 12 | 1.8 × 10−4 | 5.3 × 10−3 | IFITM5 | TSS, 5′UTR, cds | |
1 | 223316194–223317573 | 13 | 2.4 × 10−4 | 5.3 × 10−3 | TLR5 | TSS, intron, exon, 5′UTR | |
20 | 61583512–61584184 | 11 | 1.1 × 10−3 | 2.5 × 10−4 | SLC17A9 | TSS, 5′UTR, cds; exon | |
8 | 39171595–39172145 | 9 | 2.6 × 10−3 | 4.2 × 10−4 | ADAM5 | intergenic | |
14 | 24780142–24780951 | 11 | 3.3 × 10−3 | 2.1 × 10−4 | LTB4R2; CIDEB; LTB4R | 3′UTR, cds; TSS, exon, 5′UTR; exon | |
15 | 45021092–45021786 | 3 | 3.4 × 10−3 | 6.7 × 10−4 | LOC100419583 | nc_intron, nc_exon | |
14 | 96180294–96181069 | 11 | 4.5 × 10−3 | 6.7 × 10−4 | TCL1A | nc_exon; TSS, 5′UTR, cds | |
4 | 122853439–122854430 | 9 | 4.7 × 10−3 | 7.7 × 10−4 | TRPC3 | intron, cds; TSS, 5′UTR | |
21 | 15077071–15077799 | 3 | 5.5 × 10−3 | 8.1 × 10−4 | LOC110091777 | intergenic | |
3 | 122640753–122641341 | 6 | 8.3 × 10−3 | 1.1 × 10−3 | SEMA5B | nc_intron, nc_exon; intron, cds | |
20 | 42543009–42543803 | 9 | 9.4 × 10−3 | 7.3 × 10−4 | TOX2 | TSS, intron, 5′UTR, cds | |
3 | 46759071–46759723 | 9 | 0.00998 | 1.3 × 10−3 | PRSS50 | TSS, intron, 5′UTR, cds | |
Spring | 6 | 28058690–28059233 | 10 | 1.2 × 10−5 | 3.0 × 10−5 | ZSCAN12P1 | nc_exon |
19 | 827690–828195 | 6 | 2.9 × 10−4 | 1.8 × 10−4 | AZU1 | TSS, intron, 5′UTR, cds | |
11 | 368326–368939 | 16 | 6.5 × 10−4 | 2.5 × 10−4 | B4GALNT4 | intergenic | |
6 | 24646448–24646807 | 7 | 1.3 × 10−3 | 3.9 × 10−4 | KIAA0319 | intergenic | |
6 | 29648136–29648926 | 22 | 1.5 × 10−3 | 2.5 × 10−4 | ZFP57 | intron, exon, 5′UTR | |
6 | 31148307–31148773 | 16 | 4.1 × 10−3 | 9.0 × 10−4 | PSORS1C3 | nc_intron | |
6 | 29893901–29894366 | 16 | 6.0 × 10−3 | 5.9 × 10−5 | HCG4B | nc_exon | |
Summer | 7 | 1733107–1734350 | 9 | 4.0 × 10−6 | 8.9 × 10−5 | ELFN1 | intron, 5′UTR |
20 | 57425954–57427846 | 62 | 4.8 × 10−5 | 1.2 × 10−4 | GNAS, GNAS-AS1 | intron, 5′UTR, nc_exon, 3′UTR | |
7 | 50628943–50630108 | 7 | 1.3 × 10−4 | 2.0 × 10−4 | DDC | intron, 5′UTR | |
19 | 827404–828195 | 8 | 1.7 × 10−4 | 8.9 × 10−5 | AZU1 | TSS, intron, 5′UTR, cds | |
10 | 134664446–134665203 | 6 | 2.5 × 10−4 | 2.0 × 10−4 | CFAP46 | intron, cds | |
14 | 101290531–101293115 | 26 | 2.8 × 10−4 | 2.0 × 10−4 | MEG3 | nc_intron, nc_exon | |
12 | 132973282–132974687 | 8 | 3.5 × 10−4 | 2.0 × 10−4 | LOC101928416 | intergenic | |
6 | 32046638–32049288 | 15 | 3.7 × 10−4 | 3.0 × 10−3 | TNXB | intron, cds | |
12 | 133414230–133415291 | 6 | 5.1 × 10−4 | 3.7 × 10−3 | CHFR | exon, 3′UTR | |
6 | 28226860–28227507 | 11 | 1.3 × 10−3 | 3.8 × 10−4 | NKAPL; ZKSCAN4 | TSS, cds, intron, exon, 5′UTR | |
6 | 32051832–32054119 | 23 | 2.1 × 10−3 | 7.9 × 10−3 | TNXB | intron, cds | |
6 | 32039771–32041859 | 20 | 2.9 × 10−3 | 5.5 × 10−3 | TNXB | intron, cds | |
19 | 5048401–5049160 | 4 | 3.6 × 10−3 | 6.8 × 10−4 | KDM4B | intron | |
1 | 2387645–2388098 | 5 | 4.2 × 10−3 | 6.0 × 10−4 | PLCH2 | intergenic | |
7 | 24323236–24324460 | 10 | 4.3 × 10−3 | 7.3 × 10−4 | NPY | TSS, intron, 5′UTR | |
7 | 130131233–130132478 | 37 | 4.6 × 10−3 | 6.8 × 10−4 | MEST | TSS, intron, 5′UTR, cds, exon | |
7 | 1753371–1753934 | 7 | 5.0 × 10−3 | 6.8 × 10−4 | ELFN1 | intron, 5′UTR | |
2 | 27664992–27665736 | 11 | 5.6 × 10−3 | 7.1 × 10−4 | NRBP1, KRTCAP3 | exon, 3′UTR, TSS, intron, 5′UTR, cds | |
3 | 122712113–122712922 | 5 | 5.7 × 10−3 | 7.1 × 10−4 | SEMA5B | TSS, exon, 5′UTR; intron, nc_intron | |
12 | 53183483–53184111 | 6 | 5.9 × 10−3 | 5.1 × 10−4 | KRT3 | 3′UTR, cds | |
6 | 170571118–170572041 | 10 | 6.0 × 10−3 | 4.3 × 10−4 | LOC154449 | nc_intron, nc_exon | |
20 | 57414014–57415202 | 15 | 6.5 × 10−3 | 7.6 × 10−4 | GNAS-AS1, GNAS | nc_intron, TSS, 5′UTR, cds | |
10 | 35893599–35894455 | 9 | 6.6 × 10−3 | 3.6 × 10−4 | GJD4 | TSS, exon, 5′UTR | |
7 | 57484128–57484846 | 6 | 8.7 × 10−3 | 7.9 × 10−4 | MIR3147 | intergenic | |
6 | 32043004–32043764 | 5 | 8.8 × 10−3 | 4.1 × 10−4 | TNXB | intron |