Skip to main content

Table 3 Association between season of birth and DNA methylation in at-birth and childhood stratified by latitude

From: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Season of birtha

CpG

Coeff

SE

p value

FDR p value

Lambdab

CHR

Position

Mapped gene

Directionc

I2

At-birth

Higher latitude subgroup (≥ 50°N)

 Spring

cg06251958

0.0095

0.0016

2.0 × 10−9

0.001

1.01

7

102989081

PSMC2

 +  + ? +  +  +  −  −  + 

78

Lower latitude subgroup (< 50°N)

 Spring

cg01113988

 − 0.0082

0.0015

7.13 × 10−8

0.028

1.06

6

106035528

PREP

 −  −  −  +  −  −  −  −  −  −  −  + 

29.4

cg22168386

 − 0.0103

0.002

1.34 × 10−7

0.028

 

13

24205538

TNFRSF19

 −  −  −  −  +  + ? −  +  −  −  − 

40.1

cg17462107

0.003

0.0006

2.21 × 10−7

0.028

 

5

66199867

MAST4

 +  −  +  + ? +  +  +  +  +  +  − 

14.9

cg23369114d

 − 0.0086

0.0017

3.83 × 10−7

0.031

 

19

14198698

C19orf67

 − ? −  −  +  −  − ? −  −  −  − 

21.2

cg11520554

0.0022

0.0004

4.14 × 10−7

0.031

 

15

80216034

C15orf37; ST20

 +  +  +  +  +  +  +  −  +  +  −  − 

70.3

cg20954180

0.0052

0.001

4.64 × 10−7

0.031

 

3

54606265

CACNA2D3

 +  +  +  +  +  +  +  +  +  +  +  − 

23.6

 Winter

cg01801443

 − 0.0045

0.0007

1.65 × 10−10

7.77 × 10−5

1.02

6

168629778

LOC105378137

 +  −  −  −  +  − ? −  −  −  − ? −  − 

40.5

Childhood

Higher latitude subgroup (≥ 50°N)

 Winter

cg22709217

0.0129

0.0024

6.97 × 10−8

0.021

1.12

22

50311962

ALG12; CRELD2

 +  +  +  +  +  +  +  + 

36.2

cg18124955

0.0013

0.0002

1.09 × 10−7

0.021

 

2

173292329

ITGA6

 +  +  +  +  +  +  +  + 

0

  1. Significant CpGs identified in meta-analyses of EWAS summary results from 9 (≥ 50°N, N = 5580) and 12 (< 50°N, N = 3823) cohorts for the at-birth latitude analyses. The p values for the CpGs that passed the Bonferroni-corrected significance threshold (1.06 × 10−7) are shown in bold. Cohort-specific EWAS models were adjusted for sex of the child, gestational age and maternal age at delivery, maternal smoking during pregnancy, maternal socio-economic status, batch, and cell type proportions
  2. Coeff: regression coefficient (change in mean methylation compared to autumn reference); SE: standard error of the coefficient; Lambda: genomic inflation factor; CHR: chromosome; I2: a measure of between-study variability
  3. aReference season: autumn
  4. bEstimated using the BACON method of van Iterson et al. Ref [37]:
  5. c + : hyper-methylation; –: hypo-methylation
  6. dCross-reactive probe (Chen et al., Ref: [46])
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us