Table 2 Differentially methylated regions (DMRs) at birth and in childhood in different seasons
Season of birtha | CHR | Region | CpGs in the region | Šidák p valueb | Minimum p valuec | Gene (hg19) | Gene group |
|---|---|---|---|---|---|---|---|
At-birth DMRs | |||||||
Winter | 7 | 1753371–1753934 | 7 | 1.7 × 10−6 | 9.4 × 10−7 | ELFN1 | intron, 5′UTR |
16 | 8806334–8807068 | 13 | 2.5 × 10−4 | 3.9 × 10−4 | ABAT | TSS, exon, 5′UTR, intron | |
1 | 59042906–59043601 | 10 | 6.9 × 10−4 | 3.6 × 10−4 | TACSTD2 | TSS, exon | |
6 | 29690797–29692424 | 17 | 1.5 × 10−3 | 3.6 × 10−4 | HLA-F | TSS, intron, 5′UTR, cds | |
11 | 2907309–2907955 | 9 | 3.0 × 10−3 | 1.0 × 10−3 | CDKN1C | Intergenic | |
7 | 1095391–1095745 | 6 | 4.1 × 10−3 | 1.0 × 10−3 | GPR146, C7orf50 | intron, 5′UTR, intron, intron, exon, 5′UTR | |
4 | 206087–206587 | 8 | 4.3 × 10−3 | 3.6 × 10−4 | ZNF876P | nc_intron, nc_exon | |
21 | 15134466–15135068 | 3 | 7.5 × 10−3 | 1.8 × 10−3 | LOC110091777 | nc_exon | |
Spring | 11 | 368326–369217 | 24 | 2.9 × 10−8 | 2.6 × 10−9 | B4GALNT4 | intergenic |
6 | 31148307–31148773 | 16 | 3.2 × 10−7 | 1.4 × 10−7 | PSORS1C3 | nc_intron | |
6 | 29690741–29692607 | 27 | 5.8 × 10−6 | 6.4 × 10−7 | HLA-F | TSS, intron, 5′UTR, cds | |
6 | 41068528–41069073 | 8 | 5.9 × 10−6 | 5.8 × 10−7 | ADCY10P1, NFYA | nc_intron, nc_exon, exon, 3′UTR | |
12 | 132976697–132977165 | 4 | 1.2 × 10−4 | 2.4 × 10−5 | LOC101928416 | intergenic | |
17 | 17603506–17604209 | 6 | 1.6 × 10−4 | 3.9 × 10−5 | RAI1 | intron, 5′UTR | |
19 | 827690–828195 | 6 | 2.3 × 10−4 | 4.4 × 10−5 | AZU1 | TSS, intron, 5′UTR, cds | |
11 | 60534886–60535091 | 4 | 4.3 × 10−4 | 4.0 × 10−5 | MS4A15 | nc_intron, nc_exon, intron, cds, 5′UTR | |
19 | 11784489–11785150 | 10 | 4.7 × 10−4 | 8.4 × 10−7 | ZNF833P | nc_intron, nc_exon | |
12 | 6876163–6876346 | 2 | 1.3 × 10−3 | 9.3 × 10−5 | PTMS | Intron | |
11 | 1319623–1320659 | 6 | 1.2 × 10−3 | 1.3 × 10−2 | TOLLIP | intron, 5′UTR | |
20 | 35402098–35402548 | 13 | 4.2 × 10−3 | 2.5 × 10−4 | DSN1 | TSS, exon, 5′UTR | |
2 | 239139886–239140215 | 6 | 4.8 × 10−3 | 4.8 × 10−4 | LINC02610 | nc_intron, nc_exon | |
11 | 2721182–2721657 | 15 | 6.8 × 10−3 | 1. 8 × 10−4 | KCNQ1, KCNQ1OT1 | intron, nc_exon | |
11 | 47399788–47400355 | 9 | 7.6 × 10−3 | 8.1 × 10−4 | SPI1 | TSS, intron, 5′UTR, cds | |
Summer | 19 | 827690–828195 | 6 | 3.8 × 10−4 | 1.1 × 10−3 | AZU1 | TSS, intron, 5′UTR, cds |
7 | 43288610–43288914 | 4 | 9.3 × 10−4 | 1.1 × 10−3 | HECW1 | Intron | |
13 | 20392381–20392731 | 5 | 8.5 × 10−3 | 4.7 × 10−3 | ZMYM5 | intergenic | |
Childhood DMRs | |||||||
Winter | 1 | 153599454–153600181 | 8 | 9.6 × 10−13 | 9.5 × 10−11 | S100A13 | TSS, exon, 5′UTR, introns |
19 | 55476640–55477835 | 7 | 3.8 × 10−8 | 1.2 × 10−3 | NLRP2 | TSS, intron, exon, 5′UTR, nc_intron, nc_exon | |
13 | 36871621–36872371 | 14 | 4.0 × 10−8 | 4.2 × 10−7 | CCDC169, CCDC169-SOHLH2 | TSS, intron, 5′UTR, cds, exon | |
5 | 191461–192128 | 9 | 2.6 × 10−5 | 1.5 × 10−5 | LRRC14B | TSS, 5′UTR, cds | |
11 | 67383352–67384065 | 8 | 9.0 × 10−5 | 4.9 × 10−5 | DOC2GP | Intergenic | |
16 | 31159533–31159945 | 5 | 3.5 × 10−4 | 1.1 × 10−4 | PRSS36 | intron, cds | |
10 | 42862851–42863533 | 6 | 4.6 × 10−4 | 1.8 × 10−3 | LOC441666 | nc_intron, nc_exon | |
13 | 47472025–47472454 | 12 | 1.7 × 10−3 | 3.7 × 10−4 | HTR2A | Intergenic | |
13 | 113540164–113540656 | 6 | 2.9 × 10−3 | 6.0 × 10−4 | ATP11A | exon, 3′UTR | |
10 | 43447046–43447643 | 3 | 6.6 × 10−3 | 1.2 × 10−3 | LINC01264 | Intergenic | |
1 | 1003101–1003554 | 4 | 6.7 × 10−3 | 1.0 × 10−3 | LOC105378948 | nc_intron, nc_exons | |
1 | 2121014–2121546 | 4 | 7.7 × 10−3 | 1.1 × 10−3 | FAAP20, LOC112268219 | nc_intron, nc_exon, intron, exon, 5′UTR, 3′UTR, cds | |
Spring | 1 | 230415160–230415693 | 6 | 5.3 × 10−9 | 2.5 × 10−8 | GALNT2 | 3′UTR, cds |
17 | 33759459–33760318 | 11 | 1.6 × 10−7 | 1.0 × 10−5 | SLFN12 | TSS, exon, 5′UTR, intron | |
13 | 47472025–47472454 | 12 | 2.1 × 10−5 | 1.0 × 10−5 | HTR2A | Intergenic | |
3 | 193922012–193922718 | 7 | 6.9 × 10−5 | 3.7 × 10−5 | LINC02036 | nc_intron, nc_exon | |
6 | 163148828–163149478 | 6 | 2.5 × 10−4 | 1.0 × 10−5 | PACRG | intron, 5′UTR, cds, TSS | |
6 | 31543194–31543711 | 11 | 2.1 × 10−3 | 1.3 × 10−3 | TNF | TSS, intron, 5′UTR, cds | |
8 | 1094459–1094929 | 6 | 4.7 × 10−3 | 9.8 × 10−4 | DLGAP2 | Intron | |
11 | 10715150–10715385 | 6 | 4.9 × 10−3 | 2.2 × 10−3 | IRAG1 | TSS, exon, 5′UTR | |
19 | 39737743–39737886 | 3 | 8.6 × 10−3 | 6.7 × 10−4 | IFNL4 | intron, 3′UTR, cds, nc_intron, nc_exon | |
19 | 10735981–10736380 | 7 | 9.5 × 10−3 | 1.4 × 10−3 | SLC44A2 | TSS, intron, 5′UTR, cds | |
Summer | 10 | 123355243–123356361 | 9 | 3.0 × 10−8 | 3.9 × 10−7 | FGFR2 | nc_intron, TSS, intron, exon, 5′UTR |
7 | 27183108–27184878 | 47 | 5.0 × 10−7 | 2.1 × 10−6 | HOXA-AS3, HOXA3, HOXA5 | nc_intron, TSS, 5′UTR, cds | |
6 | 41394131–41395119 | 5 | 1.1 × 10−5 | 1.2 × 10−5 | LINC01276 | intergenic | |
17 | 21280992–21281532 | 5 | 2.0 × 10−5 | 1.3 × 10−5 | KCNJ12 | intron, 5′UTR | |
10 | 131697055–131698005 | 7 | 8.1 × 10−4 | 2.4 × 10−4 | EBF3 | Intron | |
1 | 247171209–247171863 | 10 | 1.0 × 10−3 | 2.4 × 10−4 | ZNF695, ZNF670-ZNF695 | TSS, 5′UTR, cds, nc_intron, nc_exon | |
5 | 2334377–2334996 | 5 | 1.7 × 10−3 | 1.4 × 10−4 | LOC100506858 | intergenic | |
10 | 42862851–42863619 | 9 | 1.7 × 10−3 | 3.7 × 10−4 | LOC441666 | nc_intron, nc_exon | |
7 | 148768516–148769245 | 3 | 4.4 × 10−3 | 8.0 × 10−4 | ZNF786 | cds | |
17 | 48278753–48279290 | 9 | 9.3 × 10−3 | 1.1 × 10−3 | COL1A1 | TSS, intron, 5′UTR, cds | |