Fig. 2
From: Global effects of identity and aging on the human sperm methylome
DNA methylation increases with age through centromeres. A Methylation and conditional coefficient of determination (\(R^2\)) for methylation \(\sim\) age, evaluated in 100 kb bins, along each chromosome. B Rainbow plot of methylation as a function of age through centromeric satellites (centromeric transition regions excluded). C Correlation of age and methylation plotted through 50 kb of chromosomes 1, 3 and 22, indicating both positive and negative correlation relative to the centromere position. D Rainbow plot of methylation as a function of age for ribosomal DNA annotations. (Donors colored as in Fig. 1.)