Fig. 1

Manhattan plot for genome-wide distribution of dmCpGs. A: for father’s any preconception smoking and B: father’s pubertal smoking starting before age 15. The red line shows genome-wide significance, the blue is the suggestive line. The y-axis represents − log10 of the p value for each dmCpG (indicated by dots) showing the strength of association. The x-axis shows the position across autosomal chromosomes. The top dmCpGs on each chromosome were annotated to the closest gene