Table 3 CpGs with DNA methylation associated with time to total CVD incidence in the EDC study with false discovery rate ≤ 0.20 by median HbA1c at baseline
Subgroup | CpG | Chromosome | Location | CpG position (hg38) | Gene symbol | Location relative to gene | Log hazard ratio per 5% methylation | Standard error | p value | False discovery rate |
|---|---|---|---|---|---|---|---|---|---|---|
HbA1c < 8.9% | cg07147033 | 1 | N_Shore | 1614234 | MIB2 | TSS1500 | 0.828 | 0.162 | 3.23E−07 | 0.10 |
|  | cg12324048 | 3 | OpenSea | 194105335 | (intergenic) | n/a | 0.936 | 0.184 | 3.55E−07 | 0.10 |
|  | cg15883830 | 1 | OpenSea | 151495627 | (intergenic) | n/a | 3.170 | 0.629 | 4.60E−07 | 0.10 |
|  | cg02768721 | 7 | S_Shore | 158428677 | PTPRN2 | Body | 2.307 | 0.471 | 9.61E−07 | 0.15 |
|  | cg16943126 | 10 | OpenSea | 132497609 | (intergenic) | n/a | 1.101 | 0.226 | 1.12E−06 | 0.15 |
|  | cg09983897 | 16 | Island | 31471963 | TGFB1I1 | TSS1500; TSS200 | 6.928 | 1.433 | 1.34E−06 | 0.15 |
HbA1c ≥ 8.9% | cg21823999 | 4 | Island | 176001929 | GPM6A | 5'UTR; Body | 6.565 | 1.218 | 7.03E−08 | 0.05 |
|  | cg23621817 | 4 | OpenSea | 40335835 | CHRNA9 | Body | − 8.608 | 1.635 | 1.40E−07 | 0.05 |
|  | cg10296867 | 17 | OpenSea | 10145671 | GAS7 | Body | 1.486 | 0.291 | 3.29E−07 | 0.07 |
|  | cg12570712 | 19 | Island | 53909630 | (intergenic) | n/a | − 1.795 | 0.362 | 6.83E−07 | 0.09 |
|  | cg01028223 | 7 | N_Shore | 875511 | GET4 | TSS1500 | − 4.048 | 0.815 | 6.85E−07 | 0.09 |
|  | cg10462017 | 7 | N_Shelf | 2144044 | MAD1L1 | Body | − 4.224 | 0.858 | 8.38E−07 | 0.09 |
|  | cg17155697 | 20 | S_Shelf | 31852835 | (intergenic) | n/a | − 3.436 | 0.709 | 1.24E−06 | 0.12 |
|  | cg22853588 | 20 | S_Shore | 36541477 | MYL9 | TSS200 | 0.486 | 0.102 | 1.83E−06 | 0.16 |
|  | cg08630171 | 9 | OpenSea | 129750961 | PTGES | Body | 4.168 | 0.878 | 2.08E−06 | 0.16 |
|  | cg18591304 | 1 | OpenSea | 209428437 | MIR205HG | TSS1500 | − 3.347 | 0.711 | 2.55E−06 | 0.16 |
|  | cg20136354 | 4 | N_Shore | 6663599 | (intergenic) | n/a | 0.540 | 0.115 | 2.63E−06 | 0.16 |