Table 2 Ten most significant (by p value) CpGs with DNA methylation associated with time to incident cardiovascular disease in the overall EDC cohort (n = 368)
Outcome | CpG | Chromosome | Location | CpG position (hg38) | Gene symbol | Location relative to gene | Log hazard ratio per 5% methylation | Standard error | p value | False discovery rate |
|---|---|---|---|---|---|---|---|---|---|---|
Total CVD | cg02768721 | 7 | S_Shore | 158428677 | PTPRN2 | Body | 1.610 | 0.318 | 4.10E−07 | 0.19 |
|  | cg14524754 | 17 | N_Shelf | 82967226 | B3GNTL1 | Body | 0.571 | 0.115 | 6.21E−07 | 0.19 |
|  | cg06648759 | 13 | OpenSea | 40318613 | (Intergenic) | n/a | 0.564 | 0.114 | 8.27E−07 | 0.19 |
|  | cg08468449 | 1 | OpenSea | 25581110 | (Intergenic) | n/a | 0.838 | 0.174 | 1.40E−06 | 0.24 |
|  | cg04219688 | 19 | OpenSea | 2410500 | TMPRSS9 | Body | − 0.917 | 0.192 | 1.86E−06 | 0.25 |
|  | cg00474854 | 18 | N_Shore | 11821776 | GNAL | Body | − 1.583 | 0.348 | 5.55E−06 | 0.44 |
|  | cg16992008 | 3 | OpenSea | 45920374 | FYCO1 | 3'UTR | 3.849 | 0.852 | 6.17E−06 | 0.44 |
|  | cg14499274 | 9 | OpenSea | 133840275 | VAV2 | Body | 0.390 | 0.086 | 6.21E−06 | 0.44 |
|  | cg21571162 | 6 | S_Shelf | 33251876 | VPS52 | Body | 0.993 | 0.222 | 7.48E−06 | 0.44 |
|  | cg05295851 | 1 | S_Shore | 9731967 | CLSTN1 | Body | − 3.511 | 0.789 | 8.59E−06 | 0.44 |