Fig. 6

Reactome functional interaction network derived from the list of loci with DNA methylation associated with 28-year CVD incidence at FDR ≤ 0.20 in the EDC cohort. Candidate loci are indicated in black font (red font indicates linker genes used only to construct the network). Solid line = involved in same reaction as inputs or are components of a shared complex, \(\to\)=activator or catalyst, –|= inhibitor, dashed line = predicted interaction. Only modules with ≥ 2 candidate loci were analyzed for pathway enrichment