DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma

Table 1 Gene set enrichment analysis (GSEA) results for comparison of hCIMP and lCIMP samples

Name	Size	ES	NES	NOM p-val	FDR q-val
E2F_TARGETS	193	0.68	3.26	0	0
G2M_CHECKPOINT	194	0.67	3.18	0	0
MYC_TARGETS_V1	195	0.55	2.67	0	0
MYC_TARGETS_V2	58	0.54	2.1	0	0
MITOTIC_SPINDLE	199	0.42	2.03	0	0
CHOLESTEROL_HOMEOSTASIS	74	0.46	1.88	0	0.0004
DNA_REPAIR	149	0.41	1.84	0	0.0003
MTORC1_SIGNALING	198	0.35	1.69	0	0.003
PANCREAS_BETA_CELLS	40	0.45	1.63	0.008	0.005
UV_RESPONSE_UP	158	0.33	1.54	0.0038	0.011
UNFOLDED_PROTEIN_RESPONSE	113	0.3	1.34	0.039	0.072
SPERMATOGENESIS	135	0.29	1.31	0.044	0.083
PI3K_AKT_MTOR_SIGNALING	105	0.3	1.29	0.056	0.095
EPITHELIAL_MESENCHYMAL_TRANSITION	199	0.27	1.29	0.037	0.091
INFLAMMATORY_RESPONSE	200	− 0.28	− 1.35	0.015	0.069
COAGULATION	138	− 0.29	− 1.36	0.027	0.065
ESTROGEN_RESPONSE_EARLY	197	− 0.28	− 1.37	0.015	0.064
ADIPOGENESIS	200	− 0.29	− 1.39	0.011	0.062
KRAS_SIGNALING_UP	200	− 0.29	− 1.41	0.009	0.054
IL6_JAK_STAT3_SIGNALING	87	− 0.33	− 1.43	0.019	0.052
COMPLEMENT	200	− 0.31	− 1.54	0	0.021
PROTEIN_SECRETION	96	− 0.38	− 1.66	0.002	0.006
BILE_ACID_METABOLISM	112	− 0.37	− 1.66	0.002	0.008
FATTY_ACID_METABOLISM	156	− 0.37	− 1.73	0	0.004
OXIDATIVE_PHOSPHORYLATION	199	− 0.37	− 1.81	0	0.003
INTERFERON_ALPHA_RESPONSE	97	− 0.46	− 2.03	0	0
ALLOGRAFT_REJECTION	200	− 0.46	− 2.21	0	0
INTERFERON_GAMMA_RESPONSE	200	− 0.45	− 2.21	0	0

The MSigDB hallmark database was used and only the pathways with FDR < 10% are shown. Pathways with NES > 0 are enriched in hCIMP compared to lCIMP and pathways with NES < 0 are enriched in lCIMP compared to hCIMP. Pathways related to immunity are highlighted in bold. ES Enrichment Score, NES Normalized Enrichment Score

ISSN: 1868-7083