Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease

Clinical Epigenetics

Table 3 Methylation difference of ABCG1 between CHD cases and controls in the prospective nested case–control study

CpG sites	Controls (N = 197) median (IQR)	CHD cases (N = 171) median (IQR)	OR (95% CI)^A per −10% methylation	p value^A	OR (95% CI)^B per −10% methylation	p value^B	FDR
ABCG1_CpG_1	0.86 (0.84–0.89)	0.87 (0.85–0.89)	0.49 (0.28–0.84)	0.010	0.45 (0.26–0.79)	0.006	0.019
ABCG1_CpG_2	0.95 (0.91–1.00)	0.94 (0.89–0.97)	1.78 (1.21–2.61)	0.003	1.58 (1.06–2.36)	0.024	0.038
ABCG1_CpG_3/cg27243685	1.00 (0.97–1.00)	0.99 (0.92–1.00)	1.60 (1.17–2.20)	0.004	1.56 (1.13–2.16)	0.007	0.019
ABCG1_CpG_4	0.96 (0.91–1.00)	0.93 (0.91–0.95)	2.73 (1.67–4.46)	6.30E-05	2.49 (1.51–4.12)	3.83E-04	0.003
ABCG1_CpG_7.10	0.56 (0.53–0.59)	0.55 (0.53–0.58)	1.75 (1.03–2.99)	0.040	1.62 (0.92–2.83)	0.094	0.107
ABCG1_CpG_8	0.39 (0.33–0.48)	0.37 (0.33–0.43)	1.42 (1.13–1.80)	0.003	1.33 (1.05–1.70)	0.021	0.038
ABCG1_CpG_9	0.39 (0.33–0.46)	0.38 (0.31–0.42)	1.21 (0.96–1.53)	0.113	1.15 (0.90–1.47)	0.255	0.255

Model A: Logistic regression adjusted for age, gender, and batch effect
Model B: Logistic regression adjusted for age, gender, smoking, alcohol consumption, hypertension, diabetes, TC, TG, HDL-C, LDL-C, and batch effect. Significant p values are in bold

ISSN: 1868-7083