Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease

Clinical Epigenetics

Table 2 Methylation difference of ABCG1 between CHD cases and controls in the case–control study

CpG sites	Controls (N = 277) median (IQR)	CHD cases (N = 287) median (IQR)	OR (95%CI)^A per −10% methylation	p value^A	OR (95%CI)^B per −10% methylation	p value^B	FDR
ABCG1_CpG_1	0.86 (0.84–0.88)	0.86 (0.82–0.89)	1.28 (0.95–1.72)	0.104	1.27 (0.91–1.77)	0.163	0.261
ABCG1_CpG_2	1.00 (0.98–1.00)	1.00 (0.99–1.00)	1.17 (0.82–1.66)	0.390	1.06 (0.72–1.55)	0.782	0.935
ABCG1_CpG_3/cg27243685	1.00 (1.00–1.00)	1.00 (1.00–1.00)	0.94 (0.79–1.12)	0.490	0.99 (0.81–1.21)	0.909	0.935
ABCG1_CpG_4	1.00 (1.00–1.00)	1.00 (1.00–1.00)	1.43 (0.83–2.47)	0.198	1.79 (0.86–3.74)	0.119	0.238
ABCG1_CpG_7.10	0.59 (0.55–0.64)	0.57 (0.52–0.61)	1.71 (1.30–2.24)	1.11E-04	1.54 (1.14–2.07)	0.005	0.020
ABCG1_CpG_8	0.53 (0.44–0.68)	0.51 (0.39–0.66)	1.05 (0.96–1.15)	0.251	1.00 (0.91–1.11)	0.935	0.935
ABCG1_CpG_9	0.42 (0.32–0.50)	0.35 (0.26–0.44)	1.25 (1.11–1.41)	1.74E−04	1.19 (1.05–1.36)	0.009	0.024

OR, odds ratio; CI, confidence interval; FDR, false discovery rate
Model A: Logistic regression adjusted for age, gender, and batch effect
Model B: Logistic regression adjusted for age, gender, smoking, alcohol consumption, hypertension, diabetes, TC, TG, HDL-C, LDL-C, and batch effect. Significant p values are in bold

ISSN: 1868-7083