Fig. 5

Receiver operating characteristic (ROC) analysis of CHD prediction in the prospective nested case–control study by the model combined ABCG1 CpG sites and baseline characteristics. The baseline characteristics were assessed as a reference model (Model 1), including age, gender, smoking, alcohol consumption, hypertension, diabetes, TC, TG, HDL-C, and LDL-C. Model 2 combined all ABCG1 CpG cites with the baseline characteristics. (A) Models’ performance for all 171 CHD cases vs. all 197 controls. (B) Models’ performance for 89 ICM cases vs. all 197 controls. (C) Models’ performance for 62 CHD cases vs. 73 controls in < 60 years old group. (D) Models’ performance for 109 CHD cases vs. 124 controls in ≥ 60 years old group. (E) Models’ performance for 97 CHD cases vs. 117 controls in females. (F) Models’ performance for 74 CHD cases vs. 80 controls in males