Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)

Clinical Epigenetics

Table 1 Classification and features of HDACs

Classification	Subtypes	Tissue specificity	Cellular location	Function	References
Class I	HDAC1, 2	NA	Nucleus	Mediate DNA damage response, regulate cardiac morphogenesis, growth, and contractility, and repress cytokine production	[7, 14]
	HDAC3	NA	Nucleus, cytoplasm, and plasma membrane	Mediate DNA repair, endochondral bone formation, mitosis, and inflammatory response	[4, 7, 11, 12, 14]
	HDAC8	Smooth muscles	Nucleus and cytoplasm	Affect contractility in smooth muscles and mediate anti-apoptosis	[7, 9, 13, 14]
Class II	IIa (HDAC4, 5, 7, 9)	Brain, heart, lungs, placenta, pancreas, skeletal muscles, and thymus	Nucleocytoplasmic shuttling	Regulate myocyte, osteocyte, and cardiomyocyte differentiation	[5, 7]
Class II	IIb (HDAC6, 10)	Heart, skeletal, muscles, brain, liver, spleen, and kidney	Cytoplasm	Regulate angiogenesis, cell motility, adhesion, polyamine metabolism, and antiviral innate immune response	[5, 7, 16, 17]
Class III	Sirtuins (SIRT1-7)	NA	Nucleus and cytoplasm, mitochondrion	Regulate mitochondrial function, autophagy and mitophagy, and mediate DNA repair	[5, 7, 23]
Class IV	HDAC11	NA	Nucleus	Regulate lipid metabolism and immunoregulation	[5, 18]

ISSN: 1868-7083