Fig. 1
From: Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
The histone or non-histone substrates for and the integrated biological effects of HDACs. The acetylation of histone substrates modulates the chromatin structure to reduce the accessibility to transcriptional regulatory proteins and subsequent gene expression. For non-histone substrates, HDACs have an impact on their activity by acetylating. In general, HDACs contribute to proliferative effects. Moreover, HDACs play a pivotal role in hematopoiesis and T-cell development. Abnormal expression or activity of HDACs is involved in the malignant transformation of PTCL in multiple ways, including intracellular derangements, protumorigenic microenvironment, and virus-mediated transformation