Fig. 3

Correlation heatmap of immune cell composition and risk factors of ACS. A Association between observed immune cell composition from blood routine tests and risk factors of ACS in 18,257 samples. B Association between immune cell composition estimated from DNA methylation profiles and risk factors of ACS in 1278 samples. All observed and estimated immune cell proportions were rank-normalized. The color label denotes the effect size (β), the standard deviation changes in the normalized cell proportion for different variable levels of risk factors of ACS. Red indicates that these factors are positively associated with immune cell proportions, while blue indicates an inverse association. The size of the square denotes the effect of factors on each cell proportion, and asterisk suggests significant association (P < 0.05). Lym, lymphocyte proportion; Mono, monocyte proportion; Neu, neutrophil proportion; CD8T, CD8⁺ T cell proportion; CD4T, CD4⁺ T cell proportion; B, B cell proportion; and NK, natural killer cell proportion